NeurOptics | Direct and consensual murine pupillary reflex metrics: establishing normative values.
pupil, pupil exam, pupil examination, pupil pressure measurement, pupil reaction, pupillary, pupillary light reflex, pupillometer, pupillometry, stroke, TBI, trauma, constriction velocity, critical care, critical care nursing, intraocular pressure, modified rankin scale, neurocritical care, neurologist, neuroscience nursing, neurosurgeon, medical devices, NIH Stroke Scoring Scale, NIHSS, ophth, ophthalmic, ophthalmic surgery, ophthalmologist, ophthalmology, opthal, optometrist to ophthalmologist, PERL
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Direct and consensual murine pupillary reflex metrics: establishing normative values.

Direct and consensual murine pupillary reflex metrics: establishing normative values.

 

Category: Applied Research

 

Hussain RZ1Hopkins SCFrohman EMEagar TNCravens PCGreenberg BMVernino SStüve O. Direct and consensual murine pupillary reflex metrics: establishing normative values., Auton Neurosci. 2009 Dec 3;151(2):164-7. doi: 10.1016/j.autneu.2009.07.021. Epub 2009 Aug 15.

 

Abstract

 

Pupillometry is a non-invasive technique, based on well-established neurophysiologic principles, that can be utilized to objectively characterize pathophysiologic demyelinating and neurodegenerative changes involving the pupillary reflex pathway. In animal models of human disorders, pupillometry derived reflex metrics could potentially be used to longitudinally monitor disease activity and responses to pharmacotherapies. These investigations would have important implications for translational initiatives focused on the identification and application of novel neuroprotective and restorative treatments for human diseases such as multiple sclerosis. Here, we have established normal reference values for various pupillary reflex metrics across different mouse strains. Ultimately, we anticipate that this new data will help to catalyze unique lines of inquiry using pupillometry methods.