Clinical Publications – Critical Care

Clinical Publications

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Intraoperative neurological pupil index and postoperative delirium and neurologic adverse events after cardiac surgery: an observational study

Seohee Lee, Dhong‑Eun Jung, Dongnyeok Park, Tae Jung Kim, Hyung‑Chul Lee, Jinyoung Bae, Karam Nam, Yunseok Jeon, Youn Joung Cho

Scientific Reports, August 2023

The Neurological Pupil index for outcome prognostication in people with acute brain injury (ORANGE): a prospective, observational, multicentre cohort study

Mauro Oddo, Fabio S Taccone, Matteo Petrosino, Rafael Badenes, Aaron Blandino-Ortiz, Pierre Bouzat, Anselmo Caricato, Randall M Chesnut, Anders C Feyling, Nawfel Ben-Hamouda, J Claude Hemphill, Julia Koehn, Frank Rasulo, Jose I Suarez, Francesca Elli, Alessia Vargiolu, Paola Rebora, Stefania Galimberti, and Giuseppe Citerio

The Lancet Neurology, August 2023

Assessing Patients with Altered Level of Consciousness

Michelle Hill, Melissa Moreda, Jacqueline Navarro, Malissa Mulkey

Journal of Critical Care Nurses, August 2023

Neurological Pupillary Index and Disposition at Hospital Discharge following ICU Admission for Acute Brain Injury

Abhijit V. Lele, Sarah Wahlster, Sunita Khadka, Andrew M. Walters, Christine T. Fong, Patricia A. Blissitt, Sarah L. Livesay, Gemi E. Jannotta, Bernice G. Gulek, Vasisht Srinivasan, Kathryn Rosenblatt, Michael J. Souter, and Monica S. Vavilala

Journal of Clinical Medicine, June 2023

Neurocritical Care Society Guidelines – Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest

Venkatakrishna Rajajee, Susanne Muehlschlegel, Katja E. Wartenberg, Sheila A. Alexander, Katharina M. Busl, Sherry H. Y. Chou, Claire J. Creutzfeldt, Gabriel V. Fontaine, Herbert Fried, Sara E. Hocker, David Y. Hwang, Keri S. Kim, Dominik Madzar, Dea Mahanes, Shraddha Mainali, Juergen Meixensberger, Felipe Montellano, Oliver W. Sakowitz, Christian Weimar, Thomas Westermaier and Panayiotis N. Varelas

Neurocritical Care, March 2023

Reflections on Patient Care Technicians Obtaining Pupillometer Readings in a Neuroscience Intensive Care Unit

Donald Stout, James Dullaway, Hannah McMahan, Blake A. Daniel, DaiWai M. Olson

Journal of Neuroscience Nursing, December 2022

Pupillary light reflex measured with quantitative pupillometry has low sensitivity and high specificity for predicting neuroworsening after traumatic brain injury

Tiffany Trent, Ayushi Vashisht, Sava Novakovic, Giovanni Kanter, Emerson Nairon, Amanda Lark, Amy Tucker, Vamsi Reddy, Morgan McCreary, Sonja E. Stutzman, DaiWai M. Olson

Journal of the American Association of Nurse Practitioners, November 2022

Impact of acute intoxication on quantitative pupillometry assessment in the emergency department

Eliana L. Jolkovsky, Felix E. Fernandez-Penny, Maya Alexis, Lauren N. Benson, Bo Hwan Wang, Benjamin S. Abella

JACEP Open, October, 2022

Evaluating the Reliability of Neurological Pupillary Index as a Prognostic Measurement of Neurological Function in Critical Care Patients

Muhammad S. Ghauri, Arisa Ueno, Sumayya Mohammed, Dan E. Miulli, Javed Siddiqi

Cureus, September, 2022

Automated Pupillometry as an Assessment Tool for Intracranial Hemodynamics in Septic Patients

Ilaria A. Crippa, Paolo Pelosi, Armin A. Quispe-Cornejo, Antonio Messina, Francesco Corradi, Fabio S. Taccone, Chiara Robba

Cells, July, 2022

Superior reproducibility and repeatability in automated quantitative pupillometry compared to standard manual assessment, and quantitative pupillary response parameters present high reliability in critically ill cardiac patients

Benjamin Nyholm, Laust Obling, Christian Hassager, Johannes Grand, Jacob Møller, Marwan Othman, Daniel Kondziella, Jesper Kjaergaard

PLOS ONE, July, 2022

A differential of the left eye and right eye neurological pupil index is associated with discharge modified Rankin scores in neurologically injured patients

Claudio M. Privitera, Sanjay V. Neerukonda, Venkatesh Aiyagari, Shoji Yokobori, Ava M. Puccio, Nathan J. Schneider, Sonja E. Stutzman, DaiWai M. Olson, END PANIC Investigators

BMC Neurology, July, 2022

Neurological pupil index during cardiopulmonary resuscitation is associated with admission to ICU in non-traumatic out-of-hospital cardiac arrest patients

Dong W. Kim, You H. Jo, Seung M. Park, Dong K. Lee, Dong-Hyun Jang

Signa Vitae, May, 2022

Neurological Pupil Index for the Early Prediction of Outcome in Severe Acute Brain Injury Patients

Federico Romagnosi, Adriano Bernini, Filippo Bongiovanni, Carolina Iaquaniello, John-Paul Miroz, Giuseppe Citerio, Fabio Silvio Taccone, Mauro Oddo

Brain Sciences, May, 2022

Inter-device reliability of the NPi-200 and NPi-300 pupillometers

Sonja Stutzman, Phebe Iype, Jade Marshall, Kinley Speir, Nathan Schneider, Conny Tran, Shannon Laird, Venkatesh Aiyagari, DaiWai Olson

Journal of Clinical Neuroscience, April, 2022

Automated pupillometry for assessment of treatment success in nonconvulsive status epilepticus

Jana Godau, Kaushal Bharad, Johannes Rösche, Gabor Nagy, Stefanie Kästner, Klaus Weber, Julian Bösel

Neurocritical Care, February, 2022

Neurological Assessment of the Adult Hospitalized Patient

Susan D. Bell, Chen-Chen T. Lee, Julie Zeeman, Michelle Kearney, Lauren Macko, Cathy C. Cartwright

American Association of Neuroscience Nurses (AANN), 2021

Neurological Assessment of the Hospitalized Child

Cathy C. Cartwright, Kentlee Battick, Jennifer Coffman, Yannira Crespo, Cindy Fagan, and Sarah Szego

American Association of Neuroscience Nurses (AANN), 2021

European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: Post-resuscitation care

Jerry P. Nolan, Claudio Sandroni, Bernd W. Bottiger , Alain Cariou, Tobias Cronberg, Hans Friberg, Cornelia Genbrugge, Kirstie Haywood, Gisela Lilja, Veronique R.M. Moulaert, Nikolaos Nikolaou,Theresa Mariero Olasveengen, Markus B. Skrifvars, Fabio Taccone, Jasmeet Soar

Journal of Intensive Care Medicine and Resuscitation, 2021

The Presence of Cataract Does Not Influence Assessment of the Pupillary Light Reflex Using Automated Pupillometry

Sonja E. Stutzman, DaiWai M. Olson, Aardhra M. Venkatachalam, Arianna Barnes, Folefac D. Atem

Journal of Health and Caring Sciences, December, 2021

Automated Pupillometry Value Differences Serve as a Prognostic Indicator Even When They are Within Normal Range

Sanjay V. Neerukonda, Nathan J. Schneider, Venkatesh Aiyagari, DaiWai M. Olson

The Journal of Neurological and Neurosurgical Nursing, December, 2021

Exploring the Relationship Between Objective Pupillometry Metrics and Midline Shift

Kathryn Giamarino, Robert Blessing, Christopher Boelter, Julie A. Thompson, Staci S. Reynolds

Journal of Neuroscience Nursing, December, 2021

Detection of opioid effect with pupillometry

Rachel Eshima McKay, Merlín D. Larson

Autonomic Neuroscience, August, 2021

Automated Infrared Pupillometer Use in Assessing the Neurological Status in Pediatric Neurocritical Care Patients: Case Reports and Literature Review

Molly E. McGetrick, Nathan Schneider, DaiWai M. Olson, Venkatesh Aiyagari, Darryl Miles

Journal of Child Science, June, 2021

Quantitative assessments of pupillary light reflexes in hospital-onset unresponsiveness

Hyunjo Lee, Soh Hyun Choi, Bobin Park, Yoon-Hee Hong, Han-Bin Lee and Sang-Beom Jeon

BMC Neurology, June, 2021

Quantitative pupillometry in patients with traumatic brain injury and loss of consciousness: A prospective pilot study.

Traylor JI, et al.

Journal of Clinical Neuroscience, June, 2021

Neurological Pupil Index as an Indicator of Irreversible Cerebral Edema: A Case Series

Michaela X. Cortes, Kathrina B. Siaron, Hend T. Nadim, Khalid M. Ahmed, JiaW. Romito

Journal of Neuroscience Nursing, April, 2021

Pupillary Light Reflex Is Not Abolished by Epinephrine and Atropine Given During Advanced Cardiac Life Support in Patients Who Achieve Return of Spontaneous Circulation

Natalie Achamallah, Jeffrey Fried, Rebecca Love, Yuri Matusov, Rohit Sharma

Journal of Intensive Care Medicine, April, 2021

Contribution of pupillary light reflex assessment to Glasgow Coma Scale for prognostication in patients with traumatic brain injury

Amna A. Butt, MD, MBBS; Folefac D. Atem, PhD; Sonja E. Stutzman, PhD; Venkatesh Aiyagari, MBBS, DM, FAHA; Aardhra M. Venkatachalam, MPH; DaiWai M. Olson, PhD, RN, CCRN, FNCS; Shoji Yokobori, MD, PhD, FJNE

Journal of Neurocritical Care, March, 2021

Abnormal neurological pupil index is associated with malignant cerebral edema after mechanical thrombectomy in large vessel occlusion patients

Ehsan Dowlati, Kwadwo Sarpong, Stanley Kamande, Austin H. Carroll, Jerome Murray, Alynna Wiley, Brendon Peterson, Jeffrey C. Mai, Jason J. Chang, Edward F. Aulisi, Rocco A. Armonda, Daniel R. Felbaum

Neurological Sciences, March, 2021

Supratentorial intracerebral hemorrhage volume and other CT variables predict the neurological pupil index

Khadijah Mazhar, DaiWai M. Olson, Folefac D. Atem, Sonja E. Stutzman, James Moreno, Aardhra Venkatachalam, Venkatesh Aiyagari

Clinical Neurology and Neurosurgery, December, 2020

Quantitative Infrared Pupillometry in Nonconvulsive Status Epilepticus

Jana Godau, Claudia Bierwirth, Johannes Rösche, Julian Bösel

Neurocritical Care, November, 2020

Automated Pupillometry as a Triage and Assessment Tool in Patients with Traumatic Brain Injury

Tarek Y. El Ahmadieh, Nicole Bedros, Sonja E. Stutzman, Daniel Nyancho, Aardhra Venkatachalam, Matthew MacAllister, Vin ShenBan Nader, S. Dahdaleh, Venkatesh Aiyagari, Stephen Figueroa, Jonathan A. White, Hunt Batjer, Carlos A. Bagley, DaiWai M. Olson, Salah G. Aoun

World Neurosurgery, October, 2020

Automated Pupillary Measurements Inversely Correlate With Increased Intracranial Pressure in Pediatric Patients With Acute Brain Injury or Encephalopathy

Ashley D. Freeman, MD; Courtney E. McCracken, PhD; Jana A. Stockwell, MD, FCCM

Pediatric Critical Care Medicine, July, 2020

Neurological Pupil Index as an Indicator of Neurological Worsening in Large Hemispheric Strokes

Tae Jung Kim, Soo‑Hyun Park, Hae‑Bong Jeong, Eun Jin Ha, Won Sang Cho, Hyun‑Seung Kang, Jung Eun Kim, Sang‑Bae Ko

Neurocritical Care, February, 2020

Neurological Pupil index for Early Prognostication After Venoarterial Extracorporeal Membrane Oxygenation

John-Paul Miroz, RN; Nawfel Ben-Hamouda, MD; Adriano Bernini, MSc; Federico Romagnosi, MD; Filippo Bongiovanni, MD; Aurélien Roumy, MD; Matthias Kirsch, MD; Lucas Liaudet, MD; Philippe Eckert, MD; and Mauro Oddo, MD

Chest Journal, February, 2020

Distributions and Reference Ranges for Automated Pupillometer Values in Neurocritical Care Patients

Bethany L. Lussier, Sonja E. Stutzman, Folefac Atem, Aardhra M. Venkatachalam, Anjali C. Perera, Arianna Barnes, Venkatesh Aiyagari, DaiWai M. Olson

Journal of Neuroscience Nursing, December 2019

Investigating the Association Between Eye Colour and the Neurological Pupil Index

Sameer Al-Obaidi, Folefac Atem, Sonja E. Stutzman, Venkatesh Aiyagari, DaiWai M. Olson

Australian Critical Care, October 2019

Impact of Increased Intracranial Pressure on Pupillometry: A Replication Study

Sameer Z. Al-Obaidi, Folefac D. Atem, Sonja E. Stutzman, DaiWai M. Olson

Critical Care Explorations, October 2019

Automated Pupillometry in Neurocritical Care: Research and Practice

Bethany L. Lussier, DaiWai M. Olson, Venkatesh Aiyagari

Neurology and Neuroscience Reports, August 2019

Neurological Pupil Index and Pupillary Light Reflex by Pupillometry Predict Outcome Early After Cardiac Arrest

Richard R. Riker, Mary E. Sawyer, Victoria G. Fischman, Teresa May, Christine Lord, Ashley Eldridge and David B. Seder

Neurocritical Care, May 2019

Quantitative pupillometry for the monitoring of intracranial hypertension in patients with severe traumatic brain injury

Fritz-Patrick Jahns, John Paul Miroz, Mahmoud Messerer, Roy T. Daniel, Fabio Silvio Taccone, Philippe Eckert and Mauro Oddo

Critical Care, May 2019

Feasibility and Variability of Automated Pupillometry Among Stroke Patients and Healthy Participants: Potential Implications for Clinical Practice

Matthew Marshall, Ritesh Deo, Charmaine Childs, Ali Ali

Journal of Neuroscience Nursing, May 2019

Correlation of Objective Pupillometry to Midline Shift in Acute Stroke Patients

Mohamed Osman, Sonja E. Stutzman, Folefac Atem, DaiWai Olson, Amber D. Hicks, Stefany Ortega-Perez, Salah G. Aoun, Ahmed Salem, Venkatesh Aiyagari

Journal of Stroke and Cerebrovascular Diseases, April 2019

Effects of Osmotic Therapy on Pupil Reactivity: Quantification Using Pupillometry in Critically Ill Neurologic Patients

C Ong, M Hutch, M Barra, A Kim, S Zafar, S Smirnakis

Neurocritical Care, April 2019

Detection of delayed cerebral ischemia using objective pupillometry in patients with aneurysmal subarachnoid hemorrhage

Salah G. Aoun, Sonja E. Stutzman, Phuong-Uyen N. Vo, Tarek Y. El Ahmadieh, Mohamed Osman, Om Neeley, Aaron Plitt, James P. Caruso, Venkatesh Aiyagari, Folefac Atem, Babu G. Welch, Jonathan A. White, H. Hunt Batjer, Daiwai M. Olson

Journal of Neurosurgery, January 2019

Pupillometry Trends in the Setting of Increased Intracranial Pressure

Molly McNett, Cristina Moran, Dawnetta Grimm, Anastasia Gianakis

Journal of Neuroscience Nursing, December 2018

Quantitative versus standard pupillary light reflex for early prognostication in comatose cardiac arrest patients: an international prospective multicenter double-blinded study

Mauro Oddo, Claudio Sandroni, Giuseppe Citerio, John-Paul Miroz, Janneke Horn, Malin Rundgren, Alain Cariou, Jean-François Payen, Christian Storm, Pascal Stammet and Fabio Silvio Taccone 

Intensive Care Medicine, November 2018

Objective Pupillometry As an Adjunct to Prediction and Assessment for Oculomotor Nerve Injury and Recovery: Potential for Practical Applications

Aoun SG, et al.

World Neurosurgery, September 2018

Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values

Ifeoluwa Shoyombo, Venkatesh Aiyagari, Sonja E. Stutzman, Folefac Atem, Michelle Hill, Stephen A. Figueroa, Chad Miller, Amber Howard & DaiWai M. Olsen  

Scientific Reports, May 2018

Implication of Neurological Pupil Index for Monitoring of Brain Edema

Tae Jung Kim, Sang-Bae Ko

Acute and Critical Care, February 2018

Saved by the pupillometer! – A role for pupillometry in the acute assessment of patients with traumatic brain injuries

Emelifeonwu J, Reid K, Rhodes J, Myles L

Brain Injury, February 2018

Integrating quantitative pupillometry into regular care in a neurotrauma intensive care unit

Anderson M, Elmer J, Shutter L, Puccio A, Alexander S

Journal of Neuroscience Nursing, February 2018

Automated Pupillometry and Detection of Clinical Transtentorial Brain Herniation: A Case Series

Papangelou A, Zink EK, Chang W-TW, Frattalone A, Gergen D, Gottschalk A, Geocadin RG

Military Medicine, February 2018

Correlations between hourly pupillometer readings and intracranial pressure values

McNett M, Moran C, Janki C, Gianakis A

Journal of Neuroscience Nursing, August 2017

Establishing normative data for pupillometer assessment in neuroscience intensive care: The “END-PANIC” Registry

Olson D, Stutzman S, Atem F, Kincaide J, Ho T, Carlisle B, Aiyagari V

Journal of Neuroscience Nursing, August 2017

Inter-device reliability of the NPi-100 Pupillometer

Zhao W, Stutzman S, DaiWai O, Saju C, Wilson M, Aiyagari V

Journal of Clinical Neuroscience, November 2016

Underestimation of Pupil Size by Critical Care and Neurosurgical Nurses

Kerr RG, Bacon AM, Baker LL, Gehrke JS, Hahn KD, Lillegraven CL, Renner CH, Spilman SK

American Journal of Critical Care, May 2016

Interrater Reliability of Pupillary Assessments

Olson D, Stutzman S, Saju C, Wilson M, Zhao W, Aiyagari V

Neurocritical Care, April 2016

The Use of Automated Pupillometry in Critical Care

Olson DM, Fishel M

Critical Care Nursing Clinics of North America, March 2016

Developmental Changes of Normal Pupil Size and Reactivity in Children

Brown JT, Connelly M, Nickols C, Neville KA

Journal of Pediatric Ophthalmology and Strabismus, May 2015

Pupillary Effects of High-dose Opioid Quantified with Infrared Pupillometry

Rollins MD, Feiner JR, Lee JM, Shah S, Larson M

Anesthesiology: The Journal of the American Society of Anesthesiologists, November 2014

Infrared pupillometry, the Neurological Pupil index and unilateral pupillary dilation after traumatic brain injury: implications for treatment paradigms

Chen JW, Vakil-Gilani K, Williamson KL, Cecil S

Springerplus, September 2014

Automated pupillometer for monitoring the critically ill patient: a critical appraisal

Zafar SF, Suarez JI

Journal of Critical Care, January 2014

Infrared pupillometry during cardiopulmonary resuscitation for prognostication—A new tool on the horizon?

Breckwoldt J, Arntz H-R

Resuscitation, July 2012

Pupillometry in anesthesia and critical care

Payen J, Isnardon S, Lavolaine J, Bouzat P, Vinclair M, Francony G

Annales Francaises d’Anesthesie et de Reanimation, June 2012

Infrared pupillometry to detect the light reflex during cardiopulmonary resuscitation: A case series

Behrends M, et al.

Resuscitation, May 2012

Pupillometry in congenital central hypoventilation syndrome (cchs): Quantitative evidence of autonomic nervous system dysregulation.

Patwari PP, Stewart TM, Rand CM, Carroll MS, Kuntz NL, Kenny AS, Brogadir CD, Weese-Mayer DE

Pediatric Research, January 2012

Pupillary reactivity as an early indicator of increased intracranial pressure: The introduction of the Neurological Pupil index

Chen JW, Gombart ZJ, Rogers S, Gardiner SK, Cecil S, Bullock RM

Surgical Neurology International, June 2011

Infrared pupillometry. Basic principles and their application in the non-invasive monitoring of neurocritical patients

Martínez-Ricarte F, Castro A, Poca MA, Sahuquillo J, Expósito L, Arribas M, Aparicio J.

Neurologia, November 2010

Infrared pupillometry as a biomarker of drug effects

Matousková O, Slanar O, Chytil L, Perlík F

Pharmacology, January 2010

Pupillometric assessment of autonomic nervous system in children with functional enuresis

Dundaroz R, Turkbay T, Erdem U, Congologlu A, Sakallioglu O, Tascilar E

International Urology and Nephrology, October 2009

Mechanism of opioid-induced pupillary effects

Larson, MD

Clinical Neurophysiology, April 2008

Gizmos and gadgets for the neuroscience intensive care unit

Bader, MK

Journal of Neuroscience Nursing, August 2006

Clinical implications of quantitative infrared pupillometry in neurosurgical patients

Fountas KN, Kapsalaki EZ, Machinis TG, Boev AN, Robinson JS, Troup EC

Neurocritical Care, May 2006

Quantitative pupillometry: normative data in healthy pediatric volunteers

Boev AN, Fountas KN, Karampelas I, Boev C, Machinis TG, Feltes C, Okosun I, Domopoulos V, Troup C

Journal of Neurosurgery: Pediatrics, December 2005

Evaluation of the portable infrared pupillometer

Du R, Meeker M, Bacchetti P, Larson MD, Holland MC, Manley GT

Neurosurgery, July 2005

Validity of simple measurement to diagnose pupillary dilation

Witting MD

American Journal of Emergency Medicine, March 2005

Pupil examination: validity and clinical utility of an automated pupillometer

Meeker M, Du R, Bacchetti P, Privitera CM, Larson MD, Holland MC, Manley G

Journal of Neuroscience Nursing, February 2005

Pupillometry in the detection of concomitant drug use in opioid-maintained patients

Murillo R, Crucilla C, Schmittner J, Hotchkiss E, Pickworth WB

Methods And Findings In Experimental And Clinical Pharmacology, May 2004

Interrater reliability in pupillary measurement

Witting MD, Goyal D

Annals of Emergency Medicine, June 2003

Assessment of autonomic function in high level athletes by pupillometry

Filipe JA, Falcao-Reis F, Castro-Correia J, Barros H

Autonomic Neuroscience, February 2003

Pupillary evaluation for differential diagnosis of coma

Tokuda Y, Nakazato N, Stein G

Postgraduate Medical Journal, January 2003

Quantitative pupillometry, a new technology: normative data and preliminary observations in patients with acute head injury

Taylor WR, Chen JW, Meltzer H, Gennarelli TA, Kelbch C, Knowlton S, Richardson J, Lutch MJ, Farin A, Hults KN, Marshall LF

Journal of Neurosurgery, January 2003

Infrared pupillometry during uncal herniation

Manley GT, Larson MD

Archives of Neurosurgery, July 2002

Pupillometric analysis of the ‘absent light reflex’

Larson MD, Muhiudeen I

Archives of Neurology, January 2001